3,5-difluoro-4-hydroxybenzylidene imidazolinone
Inventor: Samie Jaffrey
Department: Pharmacology
3,5-difluoro-4-hydroxybenzylidene imidazolinone (DFHBI) is a small molecule fluorophore. Upon binding to its aptamer, this molecule exhibits the spectral properties of enhanced green fluorescent protein (EGFP).
View PDFAnti-pro-BDNF Antibody
Inventor: Barbara Hempstead
Department: Hematology & Medical Oncology
Pro-BDNF is the uncleaved precursor form of BDNF. The anti-pro-BDNF antibody was generated by using GST-fusion protein with a peptide of BDNF as the immunogen in chickens. The antibody detects pro-BDNF, but not mature BDNF.
View PDFAnti-pro-NGF Antibody
Inventor: Barbara Hempstead
Department: Hematology & Medical Oncology
Pro-NGF is the uncleaved precursor form of NGF. The anti-pro-NGF antibody was generated by using GST-fusion protein with a peptide of NGF as the immunogen in rabbits. Unlike other antibodies generated to the mature domain of NGF, this antibody detects pro-NGF, but not mature NGF.
View PDFAntibody to mouse CD36
Inventor: Maria Febbraio, Roy Silverstein
Department: Medicine
CD36 is a cell surface class B scavenger receptor. CD36 is preferentially found within lipid rafts, which facilitates its association with receptors, signaling and adapter molecules. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It may function as a cell adhesion molecule.
View PDFChampion™ pET SUMO Expression System
Inventor: Christopher Lima
Department: Medical Sciences
The Champion™ pET SUMO Protein Expression System offers a new and important tool for high-level soluble expression of proteins and peptides with native n-termini. The companion SUMO Protease enzyme works with the great specificity and efficiency on most substrates in a wide range of temperatures without undue damage to the protein of interest.
View PDFDigycyl-Lysine Antibody, clone GX41
Inventor: Samie Jaffrey
Department: Pharmacology
This is a monoclonal antibody which recognizes a diglycine modified lysine, the trypsinized remnant of ubiquitination. The recognition does not depend on neighboring backbone amino acid sequences. It has been shown to specifically detect peptides derived from the ubiquitinated portion of proteins.
View PDFHigh Pressure Cryo-Cooler™
Inventor: Sol Gruner
Department: Physics
HPC-201 cryocooling was developed as an alternative method for cryopreservation of macromolecular crystals.
View PDFImmortalized Mouse Cardiac Endothelial Cell (MCEC) Line
Inventor: Babette Weksler
Department: Medicine
Immortalized Mouse Cardiac Endothelial Cell (MCEC) Line provides an excellent in vitro model for evaluation of the effects of specific genetic additions or deletions on endothelial physiology, because these cells can be easily and stably transfected with different genes or interest.
View PDFJK1 Passage-Independent Feeder Cells
Inventor: Marco Seandel, Shahin Rafii
Department: Cell & Developmental Biology
JK1 is capable of promoting long term culture of primitive cells, allowing for the identification of stromal derived factors that support long term proliferation of various types of stem cells. This line can be passaged serially without losing its capacity to support stem cell self renewal and survival, making it a convenient alternative to other types of feeder layers.
View PDFPARP-1 Terminal Antibody
Inventor: William Kraus
Department: Molecular Biology and Genetics
Polyclonal antibodies against the N-terminal of PARP-1, Poly [ADP-ribose] polymerase 1, a chromatin-associated enzyme that modifies various nuclear proteins. The modification is dependent on DNA and is involved in the regulation of various important cellular processes. This PARP-1 terminal antibody has been validated for use in Western blotting, chromatin IP, and reported to work in immunohistochemistry and immunoprecipitation.
View PDFRas Activation Assay
Inventor: David Shalloway
Department: Molecular Biology and Genetics
The Ras switch operates by alternating between an active, GTP-bound state and an inactive, GDP-bound state. The assay provides a simple means of quantitating Ras activation in cells. The amount of activated Ras is determined by a western blot using a Ras specific antibody. The assay can be used in research or drug discovery, and also may have applications in detecting cancer.
View PDFZymTox
Inventor: Stephane Corgie
Department: Biological and Environmental Engineering
ZymTox is a metabolic assay that is compatible with existing high-throughput screening technology. Combinations of metabolic enzymes can be included in a single screen to mimic human metabolism and thoroughly test the metabolites of consumer chemicals.
View PDFZymTrap™
Inventor: Stephane Corgie
Department: Biological and Environmental Engineering
ZymTrap is a full system of products and services from Zymtronix that takes you from finding the right enzymes for your reaction to delivering next wave biocatalysis at an industrial scale. Our system is broken down into simple phases that can each be individually tailored and optimized to meet the needs of your process. Importantly, our universal technology can work with any enzymes and so there is no need to disclose proprietary information about your enzyme or the target reaction.
