Warmblood Fragile Foal Syndrome Test
Department: Molecular Medicine
Category: Diagnostics
This invention describes a point mutation for Warmblood Fragile Foal Syndrome (WFFS) in horses and its application in genetic testing.
Warmblood Fragile Foal Syndrome (WFFS) is an inherited systemic connective tissue disorder that is prevalent in Warmblood horses. It is typified by skin hyperextensibility and fragility and afflicted foals must be euthanized.
The current invention represents the only mutation associated with WFFS of which we are currently aware. While it is not clear whether absence of this point mutation means that the tested animal is normal, as the test would not detect other distinct mutations that may cause clinically similar connective tissue fragility syndromes, proper breeding strategies for horses that are carriers of this mutation must be adopted so as to prevent avoid progeny that are homozygous for this mutation.This invention describes a point mutation for Warmblood Fragile Foal Syndrome (WFFS) in horses and its application in genetic testing.
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